Affiliations

The primary goal of this study was to analyze urinary Na + , K + and the Na + :K + excretion ratio, for associations with changes in systolic blood pressure (SBP) in participants from the DASH–Sodium trial during the initial screening period in which participants were consuming their regular diet without dietary intervention. The secondary goals of this study were to investigate: (a) the impact of the salt sensitivity of blood pressure on these responses and (b) the impact of the DASH–Sodium dietary intervention, which lowers SBP and increases dietary K + intake, on these potential associations. Our analysis reports that in the DASH–Sodium study cohort: (1) a daily excretion of <1 g K + /day is associated with elevated SBP, (2) urinary K + excretion of >1 g/day does not correlate with a reduction in SBP and, (3) a reduction in the urinary Na + :K + excretion ratio is not associated with lower SBP irrespective of the salt sensitivity of blood pressure. Collectively our data support the recent DRI recommendation not to propose a DRI for K + and suggest that further evidence is required to support the establishment of a Na + /K + excretion ratio that would reduce SBP in the general population.

Logical variables

Indicate SBP relative to urinary salt so you’re able to potassium (Na + /K + ) removal ratio at the time of assessment sufficient reason for weight-loss input regarding Dieting Remedies for Avoid Hypertension (DASH) large sodium (HS) and you will lowest salt (LS) diet for the (a) sodium sensitive (n = 71), (b) salt unwilling (letter = 119) people, philosophy found while the mean ± SD.

Significantly, we observed no association between the urinary Na + :K + ratio and SBP on the DASH HS or DASH LS dietary intervention in either SS (DASH HS R 2 = 0.04, DASH LS R 2 = 0.02) or SR (DASH HS R 2 = 0.04, DASH LS R 2 = 0.00002) participants (Fig. 5a, b). The DASH dietary intervention significantly increased the number of participants in both SS and SR groups with a urinary Na + :K + ratio of <1 on both the HS and LS diet. However, the urinary Na + :K + had no impact on SBP within dietary intake groups (Fig. 6a, b). Further, when expressed as a frequency distribution histogram the change in SBP from the DASH HS to LS dietary intervention exhibits a profound leftward shift in the SS group compared to SR group (Fig. 7a). In contrast, the frequency distribution histogram for change in the urinary Na + :K + ratio from the DASH HS to LS dietary intervention shows no difference in the Gaussian curve and distribution between SS and SR participants (Fig. 7b).

After that, multiple research has advised the blood pressure level protection evoked by K + intake tends to be determined by weight reduction Na + intake [twenty eight, 29]. Within research of your own Dashboard-Sodium dataset we seen zero association with urinary K + removal and you will SBP, in the diligent evaluating visit otherwise during the Dashboard dieting intervention whenever Na + intake are altered, indicating a versatility of one’s iamnaughty ramifications of Na + and you may K + on the SBP contained in this research. The fresh 2019 DRI Declaration determined that there was insufficient evidence to your the results regarding K + to the blood pressure levels and you can didn’t establish good DRI regarding K + . The data support the 2019 DRI Declaration and signifies that weight reduction K + supplements might not somewhat eliminate blood circulation pressure on the general populace.

Bottom line

Stamler J, Rose G, Stamler Roentgen, Elliott P, Dyer A, Marmot Meters. INTERSALT research conclusions. Social health and medical care ramifications. Blood pressure levels. 1989;–eight.